Typical HUS
نویسندگان
چکیده
منابع مشابه
Eculizumab in Typical Hemolytic Uremic Syndrome (HUS) With Neurological Involvement
In typical hemolytic uremic syndrome (HUS) approximately 25% of patients show central nervous system (CNS) involvement often leading to serious long-term disabilities. We used the C5-complement inhibitor Eculizumab as rescue therapy. From 2011 to 2014, 11 children (median age 22 months, range 11-175) with enterohemorrhagic Escherichia coli-positive HUS requiring dialysis who had seizures (11/11...
متن کاملHUS and atypical HUS.
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually categorized as typical, caused by Shiga toxin-producing Escherichia coli (STEC) infection, as atypical HUS (aHUS), usually caused by uncontrolled complement activation, or as secondary HUS with a coexisting disease. In recent years,...
متن کاملTypical Hus: Evidence of Acute Phase Complement Activation from a Daycare Outbreak
The clinical manifestations of typical hemolytic uremic syndrome (HUS) encompass a wide spectrum. Despite the potentially severe sequelae from this syndrome, treatment approaches remain supportive. We present the clinical course of a child who contracted Shiga toxin-positive E. coli (STEC) from a daycare center during an outbreak. Utilizing the modified Ham test which is a rapid, serum-based fu...
متن کاملAtypical HUS and complement dysregulation.
I n 1998, a linkage analysis in three families with atypical hemolytic uremic syndrome (aHUS) demonstrated segregation to the RCA (regulators of complement activation) cluster of genes on 1q32 (1). In one of these families, a missense mutation was found in the gene (CFH) encoding the soluble complement regulator factor H. Subsequently, more than 50 different CFH mutations have been described bo...
متن کاملTTP-HUS associated with sunitinib.
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is a rare condition that is severe and may be fatal. Adverse reactions to drugs increasingly are reported as probable causes of TTP-HUS. Many chemotherapeutic agents have also been implicated in causing TTP-HUS. We reported a woman with metastatic renal cell carcinoma who presented with TTP-HUS associated with sunitinib. Sh...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2014
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.25.706